CRMP2 Protein SUMOylation Modulates NaV1.7 Channel Trafficking
نویسندگان
چکیده
منابع مشابه
Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.
Voltage-gated sodium channels are crucial determinants of neuronal excitability and signaling. Trafficking of the voltage-gated sodium channel NaV1.7 is dysregulated in neuropathic pain. We identify a trafficking program for NaV1.7 driven by hierarchical interactions with posttranslationally modified versions of the binding partner collapsin response mediator protein 2 (CRMP2). The binding desc...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2013
ISSN: 0021-9258
DOI: 10.1074/jbc.m113.474924